MedViz – a Research & Development cluster in Bergen. MedViz is a cluster of groups performing interdisciplinary research in advanced image analysis and visualisation bridging the gap between “bench and bedside”. MedViz also includes imaging physics and fundamental biomedical translational research. Our mission is to promote the development of biomedical and clinical imaging technologies with the ultimate goal of improving diagnosis and treatment of patients. MedViz wants to develop new clinical methods for potential commercialisation by means of denovo software for analysis, decision support and visual communication.
MedViz seminar 06.11.2015

MedViz Seminar Friday 06.11.2015, MedViz Facilities, Møllendalsbakken 7, 5th floor, 12:00-13:00


Super-Resolution Microscopy

Fritz Thorsen
Title: Update on Euro-BioImaging and Super Resolution

Euro-BioImaging (EuBI) is a European imaging infrastructure, aiming to provide access, service and training to state-of-the-art imaging technologies. EuBi is soon entering the operation phase, where Norway will be represented with two imaging nodes. This lecture will summarize achievements made so far, and layout for securing open access in future, to European imaging instrumentation. One of the Norwegian nodes successfully applied to The Norwegian Research Council for funding, to purchase super resolution microscopes. This lecture will end by briefly describing principles of super resolution, with some potential applications.

Stig Ove Bøe
Title: Visualization of nuclear import activation in post mitotic cells

When cells enter mitosis, nuclear residence proteins are released into the cytoplasm due to breakdown of the nuclear envelope. At exit from mitosis, the nuclear membrane is reformed concomitant with reactivation of the nuclear import machinery and recycling of nuclear proteins from the cytoplasm to the nucleus. The process of release and recycling of nuclear proteins during mitosis have important implications for growth control, cell fate determination and tumor suppression. We have employed a number of microscopy techniques, including super-resolution microscopy, correlative light and electron microscopy and high resolution live cell microscopy to visualize mitotic transport and post mitotic nuclear import of the tumor suppressor protein promyelocytic leukemia (PML). At this seminar I will present recent, unpublished data from these studies.

Last Updated on Monday, 02 November 2015 07:25
MedViz seminar 02.10.2015

MedViz Seminar 02.10.2015, MedViz Facilities, Møllendalsbakken 7, 5th floor, 12:00-13:00

Pelvic Imaging

Frank Pfeffer
Title: New trends in rectal cancer surgery and challenges to preoperative imaging.
Oncological results of rectal cancer treatment has improved impressively over the last 2 decades. Surgical technique (total mesorectal excision, TME), multidisciplinary approach and use of preoperative radio-chemo therapy has been cornerstones. Despite this, functional results are poor and the number of  permanent stoma is high (30%). Due to a narrow pelvis, surgery can be demanding. New approaches with use of robotic surgery and combined transanal / laparoscopic surgery are promising new developments in this field.
Noeska Smit
Title: The Virtual Surgical Pelvis - Anatomical Visualization for Education and Surgical Planning
Pelvic anatomy is often considered to be complex. Pelvic oncological surgery demands excellent anatomical knowledge to completely resect tumours without damaging vital structures. In doing so, surgeons are challenged to relate 2D textbook anatomy to 3D in vivo anatomy, and rely on their visual feedback rather than tactile feedback when laparoscopic and robotic techniques are being used. In rectal cancer surgery, incomplete resections and iatrogenic nerve damage are still reported, reflecting the need to optimize anatomical education. In this talk the development and application potentials of the ‘Virtual Surgical Pelvis’ (VSP): a virtual 3D patient-specific anatomical atlas are discussed.
Last Updated on Wednesday, 30 September 2015 05:54
MedViz seminar 04.09.2015
Seminar Friday 04.09.2015, MedViz Facilities, Møllendalsbakken 7, 5th floor, 12:00-13:00


Statistical challenges and solutions in a wide range of applications

Geir Egil Eide
Title: Power and precision in clinical studies
No researcher will like to end up with false or imprecise conclusions, i.e. falsely postulating an effect (rejection error) or no effect (acceptance error). Power calculations provide the statistical tool for minimizing the risks of such errors, and should be included in every project protocol. In this introductory lecture the most basic principles for calculating the minimum number of patients necessary in the study will be presented.
Karl Ove Hufthammer
Title: A short introduction to Bland–Altman plots
Correlation cannot be used to assess agreement between two methods of clinical measurement. A popular alternative is to examine the differences between paired measurements made by the two methods on the same subjects. These differences can then be used to estimate the typical difference we would expect in future measurements, and the results can be presented visually, in what we call a Bland–Altman plot.
Ragnar Nortvedt
Title: Experimental design – a faster route towards optimum
Too many scientific studies are performed to study the effects of one variable at the time. This is time consuming, inefficient and a waste of resources. In the worst cases you may also loose important information about interaction  effects between variables and therefore never be able to model and hit the combination of variables that result in optimum responses, by this approach. The alternative multivariate approach, when you are testing several variables simultaneously, reflects the reality in nature and in practical situations in the lab or the clinic. Experimental design deals with systematic testing of effects from several variables at the time. Some examples of different types of statistical experimental design are presented in this lecture.
Last Updated on Thursday, 27 August 2015 15:41
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